The Modular Structure of COPaKB

COPaKB is configured in a modular structure according to the organellar origin. Currently, there are ten modules in COPaKB, including human heart mitochondria, human heart proteasome, human heart total lysate, murine heart mitochondria, murine heart proteasome, murine heart cytosol, murine heart nuclei, murine heart total lysate, drosophila mitochondria, and C. elegans mitochondria.

The analytical performance in using the mass spectral library component of COPaKB depends on its proteome coverage. The construction and update of the mass spectral libraries are an ongoing process. Accordingly, modules with ample training datasets are provided; additional modules can be readily incorporated when new datasets become available.

In the section below, you can see an overview of each organelle module. To see more details about each module, please click on its icon. To find a summary of training datasets, please click on the species icons. You can also download the list of proteins in each module by directly clicking on the corresponding table below.


Mitochondrion

Species Download Interactome Proteins Peptides Spectra
Protein List View 1,344 16,479 25,464
Protein List View 2,273 16,755 25,273
Protein List View 4,491 33,748 44,762
Protein List ... 1,461 7,986 11,451

Proteasome

Species Download Interactome Proteins Peptides Spectra
Protein List View 2,273 16,755 25,273
Protein List View 520 3,362 5,318

Nucleus

Species Download Interactome Proteins Peptides Spectra
Human
... ... ... ... ...
Protein List View 1,431 6,856 8,633

Cytosol

Species Download Interactome Proteins Peptides Spectra
Human
... ... ... ... ...
Protein List View 4,436 29,770 41,247